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QRISK underestimated risk of CVD in general practice patients; the Framingham score overestimated risk

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J Hippisley-Cox

Professor J Hippisley-Cox, University Park, Nottingham, UK;


Does the QRISK score predict risk of cardiovascular disease (CVD) in a validation sample of general practice patients? How does it compare with the Framingham score?



prospective cohort study.


2 validation cohorts from general practices in the UK that provided routinely collected clinical data to 1 of 2 research databases (QRESEARCH, n = 160; THIN, n = 274).


patients included in the THIN (n = 1.07 million) or QRESEARCH (n = 0.61 million) databases who were 35–74 years of age (51% women) and did not have diabetes or CVD and were not taking statins at baseline.

Description of prediction guide:

the QRISK score included traditional risk factors (age, sex, systolic blood pressure, smoking status, and total:high density lipoprotein serum cholesterol ratio) as well as social deprivation (Townsend score), family history of coronary heart disease in …

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  • Source of funding: no external funding.