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Clinical prediction guide
QRISK underestimated risk of CVD in general practice patients; the Framingham score overestimated risk

https://doi.org/10.1136/ebm.13.4.123

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    J Hippisley-Cox

    Professor J Hippisley-Cox, University Park, Nottingham, UK; Julia.hippisley-cox@nottingham.ac.uk

    STUDY QUESTIONS

    Does the QRISK score predict risk of cardiovascular disease (CVD) in a validation sample of general practice patients? How does it compare with the Framingham score?

    STUDY DESIGN

    Design:

    prospective cohort study.

    Setting:

    2 validation cohorts from general practices in the UK that provided routinely collected clinical data to 1 of 2 research databases (QRESEARCH, n = 160; THIN, n = 274).

    Patients:

    patients included in the THIN (n = 1.07 million) or QRESEARCH (n = 0.61 million) databases who were 35–74 years of age (51% women) and did not have diabetes or CVD and were not taking statins at baseline.

    Description of prediction guide:

    the QRISK score included traditional risk factors (age, sex, systolic blood pressure, smoking status, and total:high density lipoprotein serum cholesterol ratio) as well as social deprivation (Townsend score), family history of coronary heart disease in …

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    Footnotes

    • Source of funding: no external funding.