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Therapeutics
Review: little high-quality evidence is available regarding treatments for localised prostate cancer

https://doi.org/10.1136/ebm.13.5.139

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    T J Wilt

    Dr T J Wilt, University of Minnesota School of Medicine, Minneapolis, MN, USA; tim.wilt@med.va.gov

    QUESTION

    In men with localised prostate cancer, what is the evidence for effectiveness and harm of various treatments?

    REVIEW SCOPE

    Included studies evaluated treatments for localised prostate cancer (tumour stage T1 or T2). Outcomes were all-cause and disease-related mortality, biochemical and clinical progression, and adverse events.

    REVIEW METHODS

    Cochrane Library (Issue 3, 2007) and Cochrane Review Group in Prostate Diseases and Urologic Malignancies specialised register (Nov 2007) were searched for randomised controlled trials (RCTs). Other sources were searched for observational studies. 18 RCTs (n = 6482, mean age 63–73 y, mean follow-up 3–23 y), 1 pooled analysis of 3 RCTs (n = 8113, mean age 67 y, median follow-up 5.4 y), …

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    Footnotes

    • Source of funding: Agency for Healthcare Research and Quality.