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Review: limited evidence suggests that statins are safe in patients with liver disease

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M D Onofrei

Dr M D Onofrei, Providence Physician Division, Milwaukie, OR, USA;


Is statin therapy safe in patients with pre-existing liver disease?


Included studies evaluated the safety of statins available in the USA in patients with pre-existing liver disease. Outcomes were elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) concentrations or liver function tests, and survival.


Medline (Jun 2007), abstracts from major medical meetings, and references were searched for clinical trials, meta-analyses, and validation studies in English. 19 studies (n = 1563 receiving statins) met the selection criteria. Duration of follow-up ranged from 1 …

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