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Therapeutics
Review: limited evidence suggests that statins are safe in patients with liver disease

https://doi.org/10.1136/ebm.13.5.140

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    M D Onofrei

    Dr M D Onofrei, Providence Physician Division, Milwaukie, OR, USA; mihai.onofrei@providence.org

    QUESTION

    Is statin therapy safe in patients with pre-existing liver disease?

    REVIEW SCOPE

    Included studies evaluated the safety of statins available in the USA in patients with pre-existing liver disease. Outcomes were elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) concentrations or liver function tests, and survival.

    REVIEW METHODS

    Medline (Jun 2007), abstracts from major medical meetings, and references were searched for clinical trials, meta-analyses, and validation studies in English. 19 studies (n = 1563 receiving statins) met the selection criteria. Duration of follow-up ranged from 1 …

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    Footnotes

    • Source of funding: not stated.