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Metformin plus a lifestyle intervention was more effective than either alone for antipsychotic-induced weight gain

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J P Zhao

Dr J P Zhao, Second Xiangya Hospital, Changsha, China;



randomised placebo controlled trial.

Allocation concealment:



blinded (data collectors, {patients, data analysts, safety committee, and manuscript writers}†).*



schizophrenia outpatient clinic in China.


128 patients 18–45 years of age (mean age 26 y, 50% men) who were diagnosed with a first psychotic episode of schizophrenia, gained >10% of predrug weight in year 1 of antipsychotic treatment (clozapine, olanzapine, sulpiride, or risperidone), were taking only 1 antipsychotic with ⩽25% change in dose in the past 3 months, first attended the clinic or were discharged from an inpatient unit <1 year before enrolment, had relatively stable improvement (Positive and Negative Symptom Scale total score ⩽60), and had an adult caregiver who could monitor adherence. Exclusion criteria …

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  • Source of funding: Ministry of Science and Technology of the People’s Republic of China.