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J D Douketis
Dr J D Douketis, St Joseph's Healthcare, Hamilton, Ontario, Canada; jdouket@mcmaster.ca
STUDY QUESTIONS
In patients who have discontinued anticoagulant therapy after a first episode of venous thromboembolism (VTE), what is the risk of fatal pulmonary embolism (PE) and what is the case-fatality rate of recurrent VTE?
STUDY DESIGN
Design:
combined analysis of 2 inception cohorts followed for a mean 54 (range 1–120) months.
Setting:
3 hospitals in Italy (cohort study) and 16 centres in Sweden (randomised trial).
Patients:
1628 patients from the cohort study and 424 patients from the randomised trial (mean age 62 y, 53% women) who had completed ⩾3 (mean 6) months of anticoagulant therapy (unfractionated or low-molecular-weight heparin for 5–10 d, followed by a vitamin K antagonist) after a first episode of symptomatic, objectively confirmed VTE. Patients with active cancer, …
Footnotes
Source of funding: no external funding.
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