Article Text

Download PDFPDF
Risk of fatal pulmonary embolism was 0.49 per 100 person-years after discontinuing anticoagulant therapy for venous thromboembolism

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

J D Douketis

Dr J D Douketis, St Joseph's Healthcare, Hamilton, Ontario, Canada;


In patients who have discontinued anticoagulant therapy after a first episode of venous thromboembolism (VTE), what is the risk of fatal pulmonary embolism (PE) and what is the case-fatality rate of recurrent VTE?



combined analysis of 2 inception cohorts followed for a mean 54 (range 1–120) months.


3 hospitals in Italy (cohort study) and 16 centres in Sweden (randomised trial).


1628 patients from the cohort study and 424 patients from the randomised trial (mean age 62 y, 53% women) who had completed ⩾3 (mean 6) months of anticoagulant therapy (unfractionated or low-molecular-weight heparin for 5–10 d, followed by a vitamin K antagonist) after a first episode of symptomatic, objectively confirmed VTE. Patients with active cancer, …

View Full Text


  • Source of funding: no external funding.