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Review: BP-lowering drugs prevent cardiovascular events equally well in younger and older patients

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F Turnbull

Dr F Turnbull, University of Sydney, Sydney, New South Wales, Australia;


Are different classes of drugs to lower blood pressure (BP) similarly effective for preventing major cardiovascular events in younger (<65 y) and older (⩾65 y) patients?


Included studies compared drugs that lower BP with placebo, a less-intensive BP-lowering regimen, or a different class of BP-lowering drug. Primary outcome was major cardiovascular event (fatal or non-fatal stroke, myocardial infarction, or heart failure).


In a prespecifed protocol, the review was to include ongoing or planned randomised controlled trials (RCTs) that had ⩾1000 patient-years of planned follow-up per group and no results presented before July 1995 (date of protocol finalisation). Of 37 eligible trials, individual patient data were provided for 25 RCTs …

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  • Source of funding: National Health and Medical Research Council of Australia.