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Review: medication adjustment based on fractional exhaled nitric oxide did not prevent asthma exacerbations

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H Petsky

Ms H Petsky, Royal Children's Hospital, Brisbane, Queensland, Australia;


In adults and children with asthma, does medication adjustment based on fractional exhaled nitric oxide (FeNO) concentration prevent asthma exacerbations more than adjustment based on clinical symptoms?


Included studies compared adjustment of asthma medication based on FeNO concentrations with adjustment based on clinical symptoms (with or without spirometry) in adults or children with “classical” asthma. Outcomes were asthma exacerbations, symptom scores, and final and cumulative dose of inhaled corticosteroids.


Cochrane Airways Group Specialised Register of Trials, Cochrane Central Register of Controlled Trials (Issue 4, 2006), Medline and EMBASE/Excerpta Medica (to Dec 2006), Old Medline (1950–65), and references were searched for randomised controlled trials (RCTs). Authors of included trials were consulted. 4 RCTs (n = 356) met the selection criteria: 2 RCTs in children (n = 141, …

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  • Source of funding: National Health and Medical Research Council.