You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Review: medication adjustment based on fractional exhaled nitric oxide did not prevent asthma exacerbations

https://doi.org/10.1136/ebm.14.1.8

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    H Petsky

    Ms H Petsky, Royal Children's Hospital, Brisbane, Queensland, Australia; helen_petsky@health.qld.gov.au

    QUESTION

    In adults and children with asthma, does medication adjustment based on fractional exhaled nitric oxide (FeNO) concentration prevent asthma exacerbations more than adjustment based on clinical symptoms?

    REVIEW SCOPE

    Included studies compared adjustment of asthma medication based on FeNO concentrations with adjustment based on clinical symptoms (with or without spirometry) in adults or children with “classical” asthma. Outcomes were asthma exacerbations, symptom scores, and final and cumulative dose of inhaled corticosteroids.

    REVIEW METHODS

    Cochrane Airways Group Specialised Register of Trials, Cochrane Central Register of Controlled Trials (Issue 4, 2006), Medline and EMBASE/Excerpta Medica (to Dec 2006), Old Medline (1950–65), and references were searched for randomised controlled trials (RCTs). Authors of included trials were consulted. 4 RCTs (n = 356) met the selection criteria: 2 RCTs in children (n = 141, …

    View Full Text

    Footnotes

    • Source of funding: National Health and Medical Research Council.