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Clinical prediction guide
Review: D-dimer concentrations predict risk of recurrent VTE after anticoagulant therapy is stopped

https://doi.org/10.1136/ebm.14.2.59

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    J D Douketis

    Dr J D Douketis, St Joseph’s Hospital, Hamilton, Ontario, Canada; jdouket@mcmaster.ca

    QUESTION

    In patients with unprovoked venous thromboembolism (VTE), do D-dimer concentrations predict risk of recurrent symptomatic VTE after anticoagulant therapy is stopped?

    REVIEW SCOPE

    Included studies measured D-dimer concentrations at 3 weeks to 2 months after stopping anticoagulant therapy in patients with a first unprovoked VTE who received therapy for ⩾3 months. Outcome was recurrent symptomatic VTE.

    REVIEW METHODS

    Medline, EMBASE/Excerpta Medica, CINAHL, Cochrane Central Register of Controlled Trials, and reference lists (all to Mar 2008) were searched, and experts were contacted for prospective cohort studies or randomised controlled trials (RCTs). 5 prospective cohort studies and 2 RCTs (n = 1888) met the selection criteria. 4 studies enrolled consecutive patients; all studies used independent outcome assessment blinded to D-dimer results and had …

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    Footnotes

    • Source of funding: no external funding.