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Therapeutics
Intensive and standard glucose control did not differ for CV events or death in poorly controlled type 2 diabetes

https://doi.org/10.1136/ebm.14.3.73

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    STUDY DESIGN

    Design:

    randomised controlled trial (Veterans Affairs Diabetes Trial [VADT]). ClinicalTrials.gov NCT00032487.

    Allocation:

    unclear allocation concealment.*

    Blinding:

    blinded (outcome assessors).*

    STUDY QUESTION

    Setting:

    20 sites in the USA.

    Patients:

    1791 patients (mean age 60 y, 97% men) who had inadequate responses to maximum doses of an oral agent or insulin therapy. Exclusion criteria included glycated haemoglobin (HbA1c) concentration <7.5%, cardiovascular (CV) event in the past 6 months, advanced congestive heart failure (CHF), severe angina, body mass index (BMI) >40 kg/m2, serum creatinine concentration >1.6 mg/dl (141 µmol/l), and alanine aminotransferase concentration >3 times the upper normal limit.

    Intervention:

    intensive (n = 892) or standard glucose control (n = 899). Patients were given oral metformin plus rosiglitazone (BMI ⩾27 kg/m2) or oral glimepiride plus rosiglitazone (BMI <27 kg/m2). The intensive-control group …

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    Footnotes

    • Source of funding: Veterans Affairs Cooperative Studies Program; American Diabetes Association; National Eye Institute.