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Therapeutics
Clindamycin and benzoyl peroxide combined was more effective than either agent alone or placebo for acne vulgaris

https://doi.org/10.1136/ebm.14.3.85

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    STUDY DESIGN

    Design:

    randomised placebo-controlled trial.

    Allocation:

    {concealed}*.†

    Blinding:

    blinded {patients, healthcare providers, data collectors, outcome assessors, and data analysts}*.†

    STUDY QUESTION

    Setting:

    66 centres in the USA, 1 in Canada, and 1 in Belize.

    Patients:

    2813 patients ⩾12 years of age (mean age 19 y, 52% women) who had moderate-to-severe acne vulgaris (grade 3–4 on 6-grade Evaluator Global Severity Score [EGSS]); presented with 17–40 inflammatory lesions (papules, pustules, and nodules), 20–100 non-inflammatory lesions (open and closed comedones), and ⩽2 nodules; and used a washout period (1 wk–6 mo) for any prior acne treatment. Women had to use contraception during the study.

    Intervention:

    once-daily combined clindamycin phosphate 1.2% and benzoyl peroxide 2.5% gel (CP-BPO, n = 797), CP …

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    Footnotes

    • Source of funding: Arcutis Pharmaceuticals.