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Review: long-term annual conversion rate to dementia was 3.3% in elderly people with mild cognitive impairment

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In elderly people with mild cognitive impairment (MCI), what is the long-term rate of conversion to dementia?


Included studies examined the progression of MCI, defined according to accepted criteria. Outcomes were dementia or probable Alzheimer disease.


Medline, EMBASE/Excerpta Medica, and PsycINFO (to Mar 2008) were searched for cohort studies with ⩾5 years of follow-up. 15 studies (n = 2404, mean age 62–82 y) met the selection criteria. Mean follow-up was 6 years (range 5–10 y).


The cumulative conversion rate to dementia was 31% (15 studies) and to Alzheimer disease was 33% (11 studies). The table shows annual conversion rates. …

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