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cluster-randomised controlled trial (Dutch part of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care [ADDITION]). ClinicalTrials.gov NCT00237549.
blinded (patients and data collectors).†
79 general practices in the Netherlands.
498 patients 50–70 years of age (mean age 60 y, 54% men) who were newly diagnosed with type 2 diabetes by a 2-stage screening process. Patients with psychiatric or cognitive disorders, current treatment for cancer, or a poor prognosis were excluded.
intensive treatment, including special physician training and frequent follow-up by a diabetes nurse, to lower glucose concentrations (target haemoglobin [Hb] A1c concentration ⩽7.0%), blood pressure (BP, target ⩽120/80 mm Hg), and lipid concentrations (target total cholesterol concentration <3.5 mmol/l) combined with structured lifestyle education (37 practices, …
Source of funding: NovoNordisk; GlaxoSmithKline; Merck.