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Therapeutics
1 day of nitrofurantoin was not as effective as 7 days for asymptomatic bacteriuria in pregnancy

https://doi.org/10.1136/ebm.14.4.113

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    STUDY DESIGN

    Design:

    randomised controlled trial.

    Allocation:

    concealed.*

    Blinding:

    blinded (patients, healthcare providers, data collectors, and outcome assessors).*

    STUDY QUESTION

    Setting:

    antenatal clinics in 7 hospitals in Thailand, the Philippines, Vietnam, and Argentina.

    Patients:

    778 pregnant women (mean age 27 y) at 12–32 weeks of gestation who were diagnosed (by a 2-step screening process) as having asymptomatic bacteriuria caused by a micro-organism sensitive to nitrofurantoin. Women with symptoms of urinary tract infection (UTI), treatment of UTI in the current pregnancy, a condition requiring continuous steroid or antibiotic therapy, antibiotic hypersensitivity, or haematological disease (including glucose-6-phosphate dehydrogenase deficiency) were excluded.

    Intervention:

    nitrofurantoin, 100 mg orally twice daily, for 1 day (n = 386) or 7 days (n = 392). The 1-day group received placebo tablets after day 1 to …

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    Footnotes

    • Sources of funding: UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development, and Research Training in Human Reproduction; Orion Diagnostica provided dipslides and Mepha Ltd provided study drugs.