You are here

  • Home
  • Archive
  • Volume 14, Issue 4
  • Step-up and step-down treatment strategies did not differ for symptom relief at 6 months in new onset dyspepsiaCommentary

Article Text

Article menu
Download PDFPDF
Therapeutics
Step-up and step-down treatment strategies did not differ for symptom relief at 6 months in new onset dyspepsia

https://doi.org/10.1136/ebm.14.4.114

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    STUDY DESIGN

    Design:

    randomised controlled trial (Dutch study on Initial Management Of Newly diagnosed Dyspepsia [DIAMOND]). ClinicalTrials.gov NCT00247715.

    Allocation:

    concealed.*

    Blinding:

    blinded (patients, {investigators, and study personnel}†).*

    STUDY QUESTION

    Setting:

    312 primary care physician practices in the Netherlands.

    Patients:

    664 patients ⩾18 years of age (54% women) who visited their general practitioner for new onset dyspepsia (pain or discomfort in upper abdomen and originating in upper gastrointestinal tract). Exclusion criteria included gastroscopy in the past year, use of prescribed acid suppressive medication in the past 3 months, alarm symptoms (dysphagia, weight loss, anaemia, or haematemesis), pregnancy, or insufficient knowledge of Dutch.

    Intervention:

    step-up treatment (n = 341) given in 3 four-week steps: (1) antacid (aluminium oxide, 200 mg/magnesium hydroxide, 400 mg) 4 times/day, …

    View Full Text

    Footnotes

    • Source of funding: Netherlands Organisation for Health Research and Development.