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Review: adding dexamethasone to standard therapy reduces short-term relapse for acute migraine in the emergency department

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Does dexamethasone prevent relapse in patients presenting to the emergency department (ED) with acute migraine headache?


Included studies evaluated adjuvant dexamethasone for acute migraine headache diagnosed and treated in the ED and reported the proportion of patients with self-reported moderate or severe headache at 24–72 hours as an outcome. Moderate or severe headache was defined as severe headache that interferes with daily activities or requires a physician visit (last 2 categories on a 5-point scale), moderate or severe headache (last 2 categories on a 4-point scale), or presence of headache on a dichotomous scale. Other outcomes included adverse events.


Randomised controlled trials (RCTs) in which patients and treating physicians were blinded were retrieved from Medline (1950–May …

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