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Screening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk of cardiac events

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Study design


randomised controlled trial (Detection of Ischemia in Asymptomatic Diabetics [DIAD]). NCT00769275.




blinded (outcome adjudication committee).*

Study question


14 centres in the USA and Canada.


1123 patients 50–75 years of age (mean age 61 y, 54% men) who had type 2 diabetes diagnosed at ⩾30 years of age, no symptomatic or previously recognised coronary artery disease (CAD), and no history of ketoacidosis.


screening with adenosine-stress radionuclide myocardial perfusion imaging …

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  • Source of funding: National Institutes of Health; Bristol Myers-Squibb Medical Imaging; Astellas Pharma.