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Therapeutics
Screening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk of cardiac events

https://doi.org/10.1136/ebm.14.5.137

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    Study design

    Design:

    randomised controlled trial (Detection of Ischemia in Asymptomatic Diabetics [DIAD]). ClinicalTrials.gov NCT00769275.

    Allocation:

    concealed.*

    Blinding:

    blinded (outcome adjudication committee).*

    Study question

    Setting:

    14 centres in the USA and Canada.

    Patients:

    1123 patients 50–75 years of age (mean age 61 y, 54% men) who had type 2 diabetes diagnosed at ⩾30 years of age, no symptomatic or previously recognised coronary artery disease (CAD), and no history of ketoacidosis.

    Intervention:

    screening with adenosine-stress radionuclide myocardial perfusion imaging …

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    Footnotes

    • Source of funding: National Institutes of Health; Bristol Myers-Squibb Medical Imaging; Astellas Pharma.