Article Text

Download PDFPDF
Blood pressure–lowering did not improve short-term mortality or dependency in acute stroke and hypertension

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Study design


randomised placebo controlled trial (Controlling Hypertension and Hypotension Immediately Post Stroke [CHHIPS] study).




blinded (patients and researchers).*

Study question


6 centres in England, UK.


179 patients >18 years of age with a fixed neurological deficit lasting >60 min, clinical diagnosis of suspected stroke, and symptom onset within 36 hours (depressor group) and hypertension (mean systolic blood pressure [BP] level >160 mm Hg). Exclusion criteria included current antihypertensive therapy in non-dysphagic patients, contraindications to trial therapy, and significant comorbidity or life expectancy <6 months. The pressor group (symptom onset <12 h and hypotension) had only 1 patient, was discontinued, and is not reported here.


lisinopril, 5–15 mg daily (n = 58), labetalol, 50–150 mg on day 1 then 100–300 mg …

View Full Text


  • Source of funding: National Institute for Health Research Health Technology Assessment Programme.