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Therapeutics
Blood pressure–lowering did not improve short-term mortality or dependency in acute stroke and hypertension

https://doi.org/10.1136/ebm.14.5.145

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    Study design

    Design:

    randomised placebo controlled trial (Controlling Hypertension and Hypotension Immediately Post Stroke [CHHIPS] study).

    Allocation:

    concealed.*

    Blinding:

    blinded (patients and researchers).*

    Study question

    Setting:

    6 centres in England, UK.

    Patients:

    179 patients >18 years of age with a fixed neurological deficit lasting >60 min, clinical diagnosis of suspected stroke, and symptom onset within 36 hours (depressor group) and hypertension (mean systolic blood pressure [BP] level >160 mm Hg). Exclusion criteria included current antihypertensive therapy in non-dysphagic patients, contraindications to trial therapy, and significant comorbidity or life expectancy <6 months. The pressor group (symptom onset <12 h and hypotension) had only 1 patient, was discontinued, and is not reported here.

    Intervention:

    lisinopril, 5–15 mg daily (n = 58), labetalol, 50–150 mg on day 1 then 100–300 mg …

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    Footnotes

    • Source of funding: National Institute for Health Research Health Technology Assessment Programme.