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Manuka honey improved wound healing in patients with sloughy venous leg ulcers

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Study design


randomised controlled trial.




blinded (statistician).*

Study question


vascular centres, leg ulcer clinics, and acute and community care hospitals.


108 patients >18 years of age (mean age 68 y) who had a venous leg ulcer (VLU) <100 cm2 with ⩾50% of the wound bed covered in slough. Exclusion criteria were malignant ulcer, wound infection, presence of a cavity wound, use of antibiotics or oral immunosuppressants, poorly controlled diabetes, pregnancy or lactation, and previous enrolment in the study.


Wounds were cleansed with warm tap water and then treated with 5 g/20 cm2 Manuka honey (n = 54), or 3 g/20 cm2 hydrogel therapy (n = 54), weekly for 4 weeks. Use of Allevyn hydrocellular foam as …

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  • Source of funding: Research and Education Foundation in Sligo General Hospital; European Wound Management Association; Health Research Board of Ireland.