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Review: intensive glucose control reduced some CV events but did not change mortality in type 2 diabetes

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Does intensive glucose control reduce cardiovascular (CV) events and mortality in patients with type 2 diabetes mellitus?

Review scope

Included studies compared intensive glucose-lowering regimens with standard regimens (placebo, standard care, or reduced-intensity control) in stable patients with type 2 diabetes mellitus, had significant group differences in haemoglobin A1c (HbA1c) concentrations during follow-up, reported CV events as primary outcomes, and provided adequate data for outcomes of interest: non-fatal myocardial infarction (MI), coronary heart disease (CHD), stroke, and all-cause mortality. Other outcomes included HbA1c concentrations, heart failure (HF), hypoglycaemia, and weight gain.

Review methods

Medline, EMBASE/Excerpta Medica, and Cochrane Central (all 1970 to Jan 2009) and reference lists were searched for randomised controlled trials (RCTs). Experts were contacted. 5 RCTs (n = 33 040, mean age 62 y, 62% …

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