Article Text

Download PDFPDF

Review: intensive glucose control reduced some CV events but did not change mortality in type 2 diabetes
Free

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Question

Does intensive glucose control reduce cardiovascular (CV) events and mortality in patients with type 2 diabetes mellitus?

Review scope

Included studies compared intensive glucose-lowering regimens with standard regimens (placebo, standard care, or reduced-intensity control) in stable patients with type 2 diabetes mellitus, had significant group differences in haemoglobin A1c (HbA1c) concentrations during follow-up, reported CV events as primary outcomes, and provided adequate data for outcomes of interest: non-fatal myocardial infarction (MI), coronary heart disease (CHD), stroke, and all-cause mortality. Other outcomes included HbA1c concentrations, heart failure (HF), hypoglycaemia, and weight gain.

Review methods

Medline, EMBASE/Excerpta Medica, and Cochrane Central (all 1970 to Jan 2009) and reference lists were searched for randomised controlled trials (RCTs). Experts were contacted. 5 RCTs (n = 33 040, mean age 62 y, 62% …

View Full Text