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Both weight-bearing and non–weight-bearing exercise improved function in patients with knee osteoarthritis

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Study design


randomised controlled trial (RCT).


unclear allocation concealment.*


blinded (outcome assessors).*

Study question


kinesiology laboratory in Taiwan.


106 patients ⩾50 years of age (mean age 62 y, 69% women) who had bilateral knee osteoarthritis (OA) according to American College of Rheumatology criteria, radiographic changes (OA grade ⩽3, compatible with mild and moderate OA), chronic knee pain for ⩾6 months, and willingness to stop medication.


weight-bearing exercise (WBE) (n = 36), non-WBE (n = 35), or no exercise (n = 35). WBE was done in a sitting position, using an EN-Dynamic resistance device (Enraf-Nonius BV, The Netherlands). With 1 foot fixed on the pedal of the device, patients fully extended and then flexed the knee joint from 90° flexion. For non-WBE, …

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  • Source of funding: National Science Council, Executive Yuan, Taiwan.