Table of contents

Therapeutics

• Meta analysis: Increased risk of asthma death with salmeterol monotherapy compared with placebo, but not with salmeterol plus inhaled corticosteroids compared with inhaled corticosteroids alone (1 May, 2010)

  Gustavo J Rodrigo
• Systematic review with meta-analysis: Systematic review finds no difference between home-based and centre-based cardiac rehabilitation in terms of effect on mortality, morbidity and modifiable risk factors in patients with CHD (1 May, 2010)

  David R Thompson
• Randomised controlled trial: Hearing loss after bacterial meningitis is predicted by presenting status and young age; effectiveness of adjuvant dexamethasone or glycerol unclear (1 May, 2010)

  Diederik van de Beek, Matthijs C Brouwer
• Cost-effectiveness analysis: Compared with glyburide, sitagliptin associated with incremental cost-effectiveness ratio of $169 572 per QALY and exenatide with $278 935 per QALY as second-line treatment in adult diabetics in the USA (1 May, 2010)

  Wendy A Davis
• Systematic review and meta-analysis: Systematic review finds modest weight loss at 1 year but a lack of high-quality evidence to support the efficacy of programmes encouraging weight loss in older people (1 May, 2010)

  Gordon L Jensen, Pao Ying Hsiao
• Randomised controlled trial: Early childhood home visits to high-risk families may reduce maternally perpetrated intimate partner violence (1 May, 2010)

  Catherine A Taylor
• Randomised controlled trial: Uplifting results of tiotropium in moderate COPD (GOLD stage 2) (1 May, 2010)

  Huib A M Kerstjens, N H T ten Hacken
• Crossover randomised controlled trial: Study finds that the combination gabapentin plus nortriptyline reduces neuropathic pain more than either drug alone (1 May, 2010)

  Alec B O'Connor
• Randomised controlled trial: Liraglutide for weight loss: more research is needed (1 May, 2010)

  Adam Gilden Tsai
• Systematic review: Current evidence shows no reduction in mortality or re-infarction rate with early mobilisation after myocardial infarction (1 May, 2010)

  Alexander M Clark
• Cluster randomised controlled trial: Hand hygiene and face mask use within 36 hours of index patient symptom onset reduces flu transmission to household contacts (1 May, 2010)

  C Raina MacIntyre
• Systematic review: Depression screening and management programmes with staff assistance in primary care increase response and remission rates, but programmes without staff assistance do not show benefits (1 May, 2010)

  Alex J Mitchell
• Systematic review: Adverse effects of treatment in randomised controlled trials are variably and inconsistently reported (1 May, 2010)

  Jim Nuovo
• Randomised controlled trial: Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever but also reduces antibody response (1 May, 2010) Free

  Jason H Homme, Philip R Fischer
• Randomised controlled trial: Compared with low-dose losartan, high-dose losartan decreases risk of death or hospital admission for heart failure in people with heart failure who are intolerant to ACE inhibitors (1 May, 2010)

  Robert McKelvie
• Systematic review: Very-low-strength evidence suggests that combining ezetimibe or fibrate with statins is no more effective than high-dose statin monotherapy for reducing all-cause mortality (1 May, 2010)

  Alexander Tenenbaum, Enrique Z Fisman
• Randomised controlled trial: Adding live, reactive telephone counselling to self-help literature does not increase smoking cessation (1 May, 2010)

  Tim Coleman
• Systematic review: Current evidence suggests phyto-oestrogens are safe and well tolerated by postmenopausal women, with moderately increased risk of adverse gastrointestinal effects compared with placebo (1 May, 2010)

  Gertraud Maskarinec
• Randomised controlled trial: Compared with usual care, supervised exercise in primary care for people with patellofemoral syndrome does not significantly increase self-reported recovery but improves pain and function in the short term and pain in the long term (1 May, 2010)

  Bill Vicenzino
• Systematic review: Use of sedatives and hypnotics, antidepressants and benzodiazepines in older people significantly increases their risk of falls (1 May, 2010)

  Sirpa Hartikainen, Eija Lönnroos
• Randomised controlled trial: Telephone-delivered collaborative care for post-CABG depression is more effective than usual care for improving mental-health-related quality of life (1 May, 2010)

  Phillip J Tully