Table of contents

Therapeutics

• Women's Health Initiative randomised ontrolled trial: Combined estrogen plus progestin may reduce coronary heart disease risk after 5 years of use in postmenopausal women starting treatment within 10 years of menopause (3 June, 2010)

  S. Mitchell Harman
• Randomised controlled trial: Intermittent preventive treatment of infants with mefloquine reduces risk of clinical malaria in areas of moderate malaria transmission and high resistance to sulphadoxine–pyrimethamine, but safety and tolerability issues need consideration (3 June, 2010) Free

  Rose McGready
• Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms (3 June, 2010)

  Giovanni Addolorato, Lorenzo Leggio
• JUPITER randomised controlled trial: Rosuvastatin is similarly effective for primary prevention of cardiovascular disease in women as in men (3 June, 2010)

  Andrew Leventhal, Erin D Michos
• Cost-effectiveness analysis: Daily self-monitoring unlikely to be cost-effective in adults with type 2 diabetes not using insulin in Canada (3 June, 2010)

  Mayer B Davidson
• Systematic review: Insufficient evidence to recommend routine adjunctive chest physiotherapy for adults with pneumonia (3 June, 2010)

  Michalis Agrafiotis
• Randomised controlled trial: Nicotine patch plus lozenge gives greatest increases in abstinence from smoking rates at 6 months compared with placebo; smaller effects seen with nicotine patch alone, bupropion or nicotine lozenges alone or combined (3 June, 2010)

  David Gonzales
• Systematic review: Combination therapy with long-acting β-agonists plus inhaled corticosteroids is no more effective than LABA monotherapy for mortality outcomes and severe exacerbations in moderate to very severe COPD and is associated with serious adverse effects (3 June, 2010)

  Peter Anthony Frith
• Combined analysis of randomised controlled trials: Quadrivalent HPV vaccine administered to women who became pregnant during trials did not appear to adversely affect pregnancy outcome; however, use during pregnancy is not recommended (3 June, 2010)

  Karen Smith-McCune
• Systematic review: No evidence that vaccinating health care workers prevents flu in elderly residents in long-term care facilities (3 June, 2010)

  G A van Essen
• Systematic review: Most physical tests to identify lumbar-disc herniation show poor diagnostic performance when used in isolation, but findings may not apply to primary care (3 June, 2010)

  J N Alastair Gibson
• Randomised controlled trial: Training paediatricians to follow guidelines for the management of acute gastroenteritis improves guideline adherence and reduces the duration of diarrhoea in young children (3 June, 2010)

  Joel S Tieder
• Systematic review: There is a slight increase in incident diabetes risk with the use of statins, but benefits likely outweigh any adverse effects in those with moderate-to-high cardiovascular risk (3 June, 2010)

  Lokpal Bhatia, Christopher D Byrne