Context

Nothing much remains of the treatments and strategies that were applied 25 years ago in the clinical setting of an acute myocardial infarction (AMI). One of the few remaining treatments is oxygen therapy. This oxygen therapy is employed in a reflexive and ‘emergency-department based’ empirical manner as a reaction to a life-threatening situation. Oxygen therapy is still recommended in several international guidelines for the treatment of uncomplicated AMI, but this ‘reasonable’ recommendation has no true scientific background.1 2 It is to the credit of Cabello and colleagues to have explored the evidence or rather, in this case, the absence of evidence for the clinical effects of oxygen therapy at the acute phase of myocardial infarction.