Table of contents

Therapeutics

• Randomised controlled trial: Nateglinide does not reduce the incidence of diabetes or cardiovascular outcomes in people with impaired glucose tolerance and cardiovascular disease or risk factors (25 November, 2010)

  Giuseppe Derosa
• Systematic review: Statins are not associated with a decrease in all cause mortality in a high-risk primary prevention setting (11 January, 2011)

  Bernhard M Kaess, Ramachandran S Vasan
• Randomised controlled trial: Pregabalin is more effective than placebo for restless legs syndrome with mild adverse effects of daytime somnolence, headache and unsteadiness (16 November, 2010)

  Mark J Buchfuhrer
• Randomised Controlled Trial: Low-dose rosiglitazone plus metformin reduces risk of incident type 2 diabetes compared with placebo in people with impaired glucose tolerance (16 November, 2010)

  Philip D Home
• Randomised controlled trial: Large placebo-controlled RCT in myocardial infarction survivors finds that daily folic acid and vitamin B12 have no effect on risk of major vascular event (16 November, 2010)

  Alessandro Pezzini
• Systematic review: Proton pump inhibitors given before endoscopy for upper gastrointestinal bleeding do not improve survival, rebleeding or need for surgery (16 November, 2010)

  Patrick Yachimski
• Randomised controlled trial: In diabetic nephropathy, high doses of vitamin B decrease glomerular filtration rate and increase risk of the composite outcome of a vascular event or all-cause mortality compared with placebo (3 November, 2010)

  Vivek Bhalla
• Systematic review: Allergen-specific immunotherapy improves asthma symptoms compared with placebo, but the possibility of adverse effects should be considered (25 November, 2010)

  Rabia Rashid, Anthony J Frew
• Randomised controlled trial: In people with poorly controlled hypertension, self-management including telemonitoring is more effective than usual care for reducing systolic blood pressure at 6 and 12 months (25 November, 2010)

  Kenneth Earle