Table of contents

Therapeutics

• Randomised controlled trial: A 3-year lifestyle intervention for adults at moderate to high risk of cardiovascular disease is cost effective when added to standard care and improves physical health-related quality of life (6 February, 2011) Free

  Bengt Jönsson
• Cochrane systematic review: Extended colonic release low-molecular weight heparin (LMWH) not ready for use in ulcerative colitis (12 January, 2011)

  Daniel C Baumgart
• Randomised controlled trial: Percutaneous coronary intervention for acute coronary syndrome: no difference in 48-h bleeding rate or vascular access-site complications with low- or standard-dose unfractionated heparin in patients initially treated with fondaparinux (12 January, 2011)

  Amar Krishnaswamy, A Michael Lincoff
• PARTNER randomised controlled trial: In people with severe aortic stenosis unsuitable for surgery transcatheter aortic valve implantation reduces 1-year mortality compared with standard care (12 January, 2011)

  Ronak Rajani
• Systematic review: Tricyclic antidepressants reduce frequency of tension-type and migraine headaches compared with placebo, and intensity of headaches compared with SSRIs, but cause greater adverse effects (19 January, 2011)

  Paul D Molyneux
• Randomised controlled trial: Combined prophylactic β-blocker and behavioural migraine management improves 30-day migraine outcomes compared with either strategy alone, or optimised acute treatment only (19 January, 2011)

  Richard B Lipton
• Randomised controlled trials: A decision aid to enhance informed decision making about bowel cancer screening improved knowledge but reduced screening uptake (19 January, 2011)

  Joshua J Fenton
• GRASP Randomised controlled trial: Chinese acupuncture for chronic shoulder pain: 65% response rate at 6 weeks compared with 24% with sham acupuncture and 37% with standard conservative orthopaedic treatment (12 January, 2011)

  Edzard Ernst
• Randomised controlled trial: Percutaneous coronary intervention for acute coronary syndromes: no difference in 30-day efficacy or safety of high- and low-dose aspirin; double-dose clopidogrel reduces 30-day risk of cardiovascular death, myocardial infarction or stroke compared with standard dose but increases risk of major bleeding (7 February, 2011)

  Anuradha Lala, Jeffrey S Berger
• Randomised controlled trial: Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h (28 January, 2011)

  Shawn Ralston
• Cochrane systematic review: Evidence from two small randomised controlled trials suggests that probiotics may reduce the duration of persistent diarrhoea in children (24 February, 2011)

  Iva Hojsak
• Stanford GEMS randomised controlled trial: A programme of culturally tailored dance plus an intervention to reduce screen media use does not reduce BMI over 2 years compared with health education in preadolescent low-income African American girls but does reduce depressive symptoms and lipid levels (8 March, 2011)

  Marilyn S Nanney
• Randomised controlled trial: Symptomatic carotid stenosis: relative to endarterectomy, stenting increases short-term risk of stroke or death in those aged over 70 years but not in younger patients (3 March, 2011)

  Martin Wiesmann
• Randomised controlled trial: Morning-only polyethylene glycol preparation for afternoon colonoscopy is superior to traditional evening-before preparation (8 March, 2011)

  Suryakanth R Gurudu