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Randomised controlled trial
Eplerenone reduces risk of cardiovascular death or hospitalisation in heart failure patients with reduced ejection fraction
  1. Andrew Ambrosy1,
  2. Mihai Gheorghiade1
  1. 1Center for Cardiovascular Innovation, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
  1. Correspondence to Mihai Gheorghiade
    Cardiovascular Center for Drug Development, Duke University, 645 North Michigan Avenue, Suite 1006, Chicago, IL 60611, USA; m-gheorghiade{at}northwestern.edu

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Context

Mineralocorticoid receptor antagonists (MRAs) have been shown to decrease all-cause mortality and cardiovascular (CV) hospitalisation in patients with moderate-to-severe heart failure (HF) (ie, New York Heart Association (NYHA) class III and IV symptoms) with a reduced ejection fraction (EF)1 and in patients with acute myocardial infarction complicated by HF with systolic dysfunction.2 The aim of EMPHASIS-HF was to investigate the effects of eplerenone, in addition to evidence-based background therapy, on clinical outcomes in patients with mild HF (ie, NYHA class II symptoms) with a reduced EF.

Methods

Patients ≥55 years of age with NYHA functional class II symptoms, an EF ≤30%, treated with an ACE inhibitor/angiotensin receptor blocker and a β-blocker, and a history of CV-related hospitalisation within the past 6 months were enrolled. Patients …

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Footnotes

  • Competing interests MG has received consulting fees from Bayer Schering Pharma AG, DebioPharm SA, Medtronic, Novartis Pharma AG, Otsuka Pharmaceuticals, Sigma Tau, Solvay Pharmaceuticals and Pericor Therapeutics. He is also a consultant for Abbott Labs, Astellas, Astra Zeneca, Bayer Schering Pharma AG, CorThera, Cytokinetics, DebioPharm SA, Errekappa Terapeutici (Milan, Italy), GlaxoSmithKline, Johnson & Johnson, Medtronic, Merck, Novartis Pharma AG, Otsuka Pharmaceuticals, Pericor Therapeutics, Protein Design Laboratories, Sanofi Aventis, Sigma Tau, Solvay Pharmaceuticals. AA has no competing interests.

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