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Low bone mineral density has been identified as a risk factor for osteoporotic fracture1 and fracture in childhood.2 Vitamin D supplementation in childhood may be a clinical strategy to maximise peak bone mass in children and, in turn, improve bone mineral density and reduce fracture risk in adulthood. However, the effectiveness of vitamin D supplementation for improving bone density in children is unclear. Therefore, Winzenberg and colleagues performed a systematic review and meta-analysis to evaluate the efficacy of vitamin D supplementation for improving paediatric bone mineral density, including how supplement dose and baseline vitamin D status may impact the outcome.
This is a systematic review and meta-analysis of studies with the following inclusion criteria: (1) randomised placebo controlled trial …
Competing interests LMR has salary support through a K23 Mentored Patient-Oriented Research Career Development Award from the National Center for Research Resources at the National Institutes of Health, Bethesda, Maryland, USA for the project ‘Analysis of bone health in African American children with fractures’.