Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
In 2009, there were more than 9 million new cases of tuberculosis, but only 63% were diagnosed. The situation for multidrug-resistant tuberculosis (MDR-TB) was even more dismal, with less than 12% of the estimated 250 000 cases diagnosed.1 The most important cause for the diagnostic gap was the absence of a rapid and sensitive test. Smear microscopy, the most widespread first-line diagnostic, is cheap and simple but has poor sensitivity and cannot detect resistance. Culture is highly sensitive and can identify drug resistance, but it requires a sophisticated laboratory infrastructure and is slow. Following a large evaluation study,2 the WHO recommended Xpert MTB/RIF (Xpert), a highly automated real-time PCR assay, as the initial diagnostic test for people suspected …
Competing interests None.