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Atrial fibrillation (AF) is a common dysrhythmia associated with reduced quality of life, higher risk of developing heart failure, cognitive impairment and increased mortality.1,–,3 Patients with AF have a five-fold increased risk of stroke, and up to 25% of all strokes in the elderly are a consequence of AF.4 Vitamin K antagonists (VKAs) reduce the risk of stroke in patients with AF by 64% compared with placebo.5 Unfortunately, many patients at risk for AF-related stroke do not take VKA for a variety of reasons.6,–,8 Aspirin is an alternative antithrombotic strategy which is less effective than VKA but probably more effective than …
Competing interests RDL and DAG are members of the ARISTOTLE trial's Steering Committee.