Article Text

Download PDFPDF
Randomised controlled trial
Calcium supplements may increase the risk of cardiovascular events in postmenopausal women
  1. Barbara J Boucher
  1. Centre for Diabetes, The Blizard Institute, Queen Mary University of London, London, UK
  1. Correspondence to Barbara J Boucher
    Centre for Diabetes, The Blizard Institute, 2 Newark Street, London E12AT, UK; bboucher{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlAbstract/FREE Full Text


Calcium supplementation is widely used for osteoporosis (OP) prevention and treatment. Many women buy calcium supplements, ±vitamin D. The authors' earlier randomised controlled trial (RCT) and meta-analysis suggests that calcium supplementation increases cardiovascular-event risks provoked controversy, as has this report.1,,3


The ‘Women’s Health Initiative Calcium/vitamin D Supplementation Study' (WHICaD) limited access data set of 36 282 community-dwelling postmenopausal women comparing calcium plus vitamin D with placebo over 7 years was re-examined for effects of personal (preprotocol) calcium usage, adjusted for other cardiovascular disease (CVD) risk factors, followed by meta-analysis of the data on non-personal calcium users and from eight similar studies (some data previously unpublished; …

View Full Text


  • Competing interests None.