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Proton pump inhibitors (PPIs) block the final step in gastric acid production, increasing intragastric pH from about 1 to above 4, depending on the agent and dose used.1 This increase may influence the fate of drugs in the stomach. In the case of acetylsalicylic acid (ASA), neutralisation of gastric contents significantly decreases the absorption of both ASA and salicylic acid,2 but the clinical significance of this is uncertain. While lansoprazole does not influence the effect of low-dose enteric-coated ASA on …
Competing interests None.