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Data comparing surgery versus watchful waiting for prostate cancer are important, and the results are also relevant when evaluating whether and when screening for prostate cancer is effective.1 Thus, deciding whether such study results are valid, and how well they generalise, is a prominent challenge in men's health.
This randomised trial seeks to determine whether mortality from prostate cancer is lower after radical prostatectomy than with primary expectant management. As an ongoing project for more than 20 years, prior major reports appeared in 2002,2 20053 and 2008.4 The …