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Systematic review
Systematic review of observational studies finds increased risk of fracture among older adults taking a proton pump inhibitor
  1. Peter Vestergaard
  1. The Osteoporosis Clinic, Aarhus University Hospital, Aarhus, Denmark
  1. Correspondence to: Peter Vestergaard
    The Osteoporosis Clinic, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus DK-8000 Denmark; p-vest{at}

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Proton pump inhibitors (PPIs) were initially considered to be potentially beneficial for bone as they were perceived to be able to inhibit acidic degradation by osteoclasts and thus have antiresorptive potential.1 However, this has been shown not to be the case, as the original studies were based on compounds differing from those used clinically.1 Studies of bone density have failed to show any major changes in bone density with PPIs.2 Short-term studies have failed to show an effect on calcium absorption by PPIs.3

The present study examines whether a relationship exists between the use of …

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  • Competing interests None.