Table of contents

Therapeutics

• Randomised controlled trial: Meta-analysis: vertebroplasty for vertebral compression fracture ineffective in improving pain and function (1 November, 2011)

  Bruce M Frankel, Vibhor Krishna
• Randomised controlled trial: Telaprevir triple combination therapy, and dual peginterferon α-2a/ribavirin therapy for 24 weeks for those with rapid-early response is not inferior to 48 weeks of therapy for treatment-naïve patients with genotype 1 hepatitis C virus infection (31 January, 2012)

  Mark Danta
• Randomised controlled trial: The use of 50% nitrous oxide improves successful intravenous access in obese and growth-limited children in an outpatient setting (19 January, 2012)

  David Rosen
• Randomised controlled trial: Physical education combined with pedometer use is associated with better glucose tolerance among overweight/obese with impaired glucose tolerance; no benefit for education alone (31 January, 2012)

  Caroline R Richardson
• Randomised controlled trial: Overweight and obese individuals following either commercial or primary care-led weight loss programmes achieve significant weight loss at the end of the 12-week programme, but only the commercial programmes studied had sustained effect to 1 year (31 January, 2012)

  Peter S W Davies
• Randomised controlled trial: For people with non-valvular atrial fibrillation rivaroxaban is non-inferior to warfarin for preventing stroke or embolism, with no difference in the risk of clinically relevant bleeding (18 February, 2012)

  Matthew Sherwood, Jonathan P Piccini
• Randomised controlled trial: Lung cancer screening with chest radiography has no effect on lung cancer incidence or mortality (18 February, 2012)

  Joshua J Fenton
• Randomised controlled trial: Vitamin E and selenium do not decrease prostate cancer incidence: vitamin E may actually increase it (3 February, 2012)

  Samay Jain, Ravi Munver, Ihor S Sawczuk
• Randomised controlled trial: In people with hand osteoarthritis, chondroitin sulphate therapy for 6 months improves pain and function compared with placebo (5 April, 2012)

  Jean-Yves Reginster
• Randomised controlled trial: Preterm infants receiving heel lance procedures have slightly lower pain scores and quicker time to return to baseline heart rate when held in kangaroo care by the mother than by the father (7 March, 2012)

  Vibhuti Shah, Ann Jefferies
• Systematic review: Thromboprophylaxis in medical inpatients reduces pulmonary embolism, increases the risk of major haemorrhage and does not reduce total mortality, producing questionable net clinical benefit (14 March, 2012)

  Mark Crowther, David G Gracia
• Randomised controlled trial: Cryotherapy for plantar warts more costly but no more effective than salicylic acid self-treatment (29 February, 2012)

  Sjoerd C Bruggink, Willem J J Assendelft
• Systematic review with meta-analysis: Lifestyle modifications and pharmacotherapy for cardiovascular risk factors are associated with improvements in erectile dysfunction (14 March, 2012)

  Kew-Kim Chew