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Randomised controlled trial
Meta-analysis: vertebroplasty for vertebral compression fracture ineffective in improving pain and function
  1. Bruce M Frankel,
  2. Vibhor Krishna
  1. Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA
  1. Correspondence to Bruce M Frankel
    Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas St., Suite 428 CSB, Charleston, SC 29425, USA; frankel{at}

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Osteoporotic vertebral compression fractures (VCF) are a significant public health concern worldwide. Percutaneous vertebral augmentation or vertebroplasty was introduced to alleviate the pain and reduce the disability associated with VCF in patients failing conservative therapy, but were at very high-risk for open surgery. Due to the apparent success and low morbidity of vertebroplasty, these indications were expanded and widespread use ensued until several randomised trials evaluated the efficacy of vertebroplasty in VCF.1,,5 Of these, two double-blind sham-controlled randomised trials (ie, the INVEST and Australian trials) …

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  • Competing interests None.