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The Selenium and vitamin E Cancer Prevention Trial (SELECT)1 trial was designed to determine whether oral selenium, vitamin E or both could affect a man's risk of being diagnosed with prostate cancer. Interim analysis of the trial had shown no benefit to supplementation with selenium and vitamin E on the incidence of prostate cancer. The study by Klein et al presents updated results from a longer follow-up period.
The effect of selenium and vitamin E on the risk of prostate cancer was studied in 35 151 study subjects. Men were eligible if they were at least 55 years old (50 years old for African–American men), had a normal digital rectal exam …
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