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Effective pharmacological prophylaxis reduces venous thromboembolism (VTE) in high-risk medically-ill patients.1 But the net benefit of VTE prevention strategies in unselected medical patients is not established.
Lederle et al conducted a comprehensive meta-analysis of available clinical trials. Articles were identified by searching MEDLINE from 1950 through April 2011 and the Cochrane Library. A comprehensive search strategy was provided including details of searches for unpublished material, with good attention to study quality and a data extraction protocol. Studies providing separate data for medical patients or stroke patients in acute or intermediate care, healthcare facilities were included. The analysis included data from randomised trials that provided clinical outcomes and evaluated therapy with heparins or mechanical devices. Studies were included …
Competing interests MC has assisted in the development of educational material and/or sat on advisory boards for Bayer, Boehringer Ingelheim, Pfizer, Leo Pharma, CSL Behring and Octapharma. He is a Career Investigator of the Heart and Stroke Foundation of Ontario and holds the Leo Pharma Chair in Thromboembolism Research at McMaster University. DG has chaired or served on advisory boards for Boehringer Ingelheim, Bristol Meyers Squibb and Daiichi Sankyo and he has contributed to the development of educational materials used by Boehringer Ingelheim