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Systematic review with meta-analysis
Lifestyle modifications and pharmacotherapy for cardiovascular risk factors are associated with improvements in erectile dysfunction
  1. Kew-Kim Chew
  1. Department of Men's Health, Keogh Institute for Medical Research, Perth, Australia
  1. Correspondence to Kew-Kim Chew
    Department of Men's Health, Keogh Institute for Medical Research, A Block, Queen Elizabeth II Medical Centre, Perth, WA 6009, Australia; kewkimchew{at}

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Pharmacotherapies directly targeted towards the pathophysiology of erectile dysfunction (ED) are efficacious. But whether lifestyle modification and other pharmacotherapies that target one of the main underlying risks for ED, cardiovascular (CV) risk factors and disease can improve ED remains unclear.


An online search of peer-reviewed databases was conducted for randomised controlled clinical trials of lifestyle modification or pharmacotherapy of CV risk factors with a minimum intervention period of 6 weeks. Study selection was undertaken with a hierarchical approach by two of the authors acting independently.

Erectile function was assessed with the 5-item International Index of Erectile …

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  • Competing interests None.