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Cohort study
Patients on three times-weekly haemodialysis have increased mortality during the long, 2-day interdialytic interval
  1. Rajiv Agarwal
  1. Indiana University and RLR VA Medical Center, Indianapolis, Indiana, USA
  1. Correspondence to Rajiv Agarwal
    Indiana University and RLR VA Medical Center, 1481 West 10th Street, 111N, Indianapolis, IN 46202, USA; ragarwal{at}

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People on long-term haemodialysis are dialysed three times-weekly such as on Mondays, Wednesdays and Fridays. Accumulation of volume and toxins over the longer 2-day interdialytic interval (eg, Friday–Monday) may provoke excess deaths. The cohort study by Foley et al asked the question whether compared with other days, morbidity and mortality is increased during the long interdialytic interval.


The participants were 32 065 adults in the USA who participated in the End-Stage Renal Disease (ESRD) Clinical Performance Measures Project at the end of calendar years 2004 through 2007. Patients were excluded if they were not receiving haemodialysis three times weekly. The outcomes were various causes of morbidity and mortality and their relationship with the …

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  • Competing interests None.