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Forty-month trial suggests repeated hyaluronic acid injections for people with knee osteoarthritis may act as a long-term slow acting drug
  1. Xavier Chevalier
  1. Correspondence to Xavier Chevalier
    Department of Rheumatology, Hopital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Creteil 94010, France; Xavier.Chevalier{at}

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Hyaluronic acid (HA) injections are recommended in the management of knee osteoarthritis (OA) by international societies because of their long-term effect.1 ,2


AMELIA is the longest (3 years) randomised, placebo controlled trial in patients with symptomatic knee OA. Eligible patients were men and women (>45 years) with knee OA and pain of 55 mm or greater on a visual analogue scale. Participants were given four cycles of five weekly intra- articular injections of HA (2.5 ml 1% sodium hyaluronate) or placebo (2.5 ml of saline solution). Follow-up was conducted at …

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  • Competing interests None.