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Randomised controlled trial
Single-tablet double-dose famotidine plus ibuprofen decreases endoscopic upper GI ulcers compared with ibuprofen alone
  1. Kentaro Sugano
  1. Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  1. Correspondence to: Kentaro Sugano
    Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, Japan; sugano{at}

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Non-steroidal anti-inflammatory drugs (NSAID) are widely prescribed worldwide. However, NSAID use frequently accompanies gastrointestinal (GI) injury including complications such as bleeding and perforation. Therefore co-therapy with gastroprotective drugs especially for those at risk has been advocated in current guidelines1 in which proton-pump inhibitors (PPI) and misoprostol are recommended to reduce NSAID-induced gastroduodenal ulcers. Another approach is to use cyclooxygenase-2 (COX-2) specific inhibitors.1 The role of histamine-2 receptor antagonists (H2RAs), however, remains uncertain in this regard. The only H2RA that …

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  • Competing interests KS has received research grants from Takeda Pharmaceuticals, Eisai Pharmaceuticals, Astellas Pharmaceuticals and Astra-Zeneca Japan. He is also a consultant for Takeda Pharmaceuticals and Astra-Zeneca Japan and has received lecture fees from Takeda Pharmaceuticals.