Table of contents

Therapeutics

• Randomised controlled trial: Cessation of donepezil is associated with clinical decline in patients with moderate-to-severe Alzheimer's disease compared to continuation of donepezil or addition or substitution of memantine (26 June, 2012)

  Pierre N Tariot
• Randomised controlled trial: Exercise may be beneficial for patients with chronic severe sciatica who would normally qualify for surgery (14 August, 2012)

  Margareta C Nordin, Federico Balagué
• Randomised controlled trial: Coronary CT angiography reduces unnecessary admissions and allows safe discharge of emergency department patients with low-to-intermediate risk chest pain (31 July, 2012)

  Adam J Singer, Michael Poon
• Systematic review and meta-analysis: Tranexamic acid reduces blood transfusion in surgical patients while its effects on thromboembolic events and mortality are uncertain (4 August, 2012)

  Raviraj Raveendran, Jean Wong
• Systematic review with meta-analysis: Non-operative management of uncomplicated acute appendicitis: using antibiotics is effective and decreases morbidity (14 August, 2012)

  Rodney J Mason
• Randomised controlled trial: Bariatric intervention effective at reversing Type 2 diabetes (25 August, 2012)

  Luigi Meneghini
• Randomised controlled trial: Thromboprophylaxis in heart failure patients with sinus rhythm: aspirin and warfarin lead to similar cardiovascular outcomes (23 August, 2012)

  Klaus K A Witte, Haqeel A Jamil
• Systematic review and meta-analysis: Mild biliary pancreatitis: interval (delayed) cholecystectomy is associated with readmission for recurrent biliary events (27 July, 2012)

  Vincenzo Neri
• Systematic review and meta-analysis: Dietary interventions more effective than physical activity or mixed interventions for weight management during pregnancy (25 August, 2012)

  Hora Soltani
• Systematic review with meta-analysis: Metformin may not reduce cardiovascular risk or all-cause mortality (14 August, 2012)

  Matteo Monami