Article Text

Download PDFPDF
Randomised controlled trial
Modest cancer prevention benefit with long-term multivitamin supplementation: Physicians’ Health Study II results warrant cautious interpretation
  1. Wendy Demark-Wahnefried
  1. Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama, USA
  1. Correspondence to Wendy Demark-Wahnefried
    Department of Nutrition Sciences, University of Alabama, 1675 University Blvd rm. 346, Birmingham, AL 35294, USA; demark{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on OpenUrlCrossRefPubMedWeb of Science


Various vitamins and minerals have been shown to inhibit carcinogenesis or reduce cancer risk in preclinical experiments and observational studies. Such work has given rise to several chemoprevention trials of isolated nutrients, many of which (eg, Alpha-Tocopherol and Beta-Carotene (ATBC) Trial, Carotene and Retinol Efficacy Trial (CARET) and Selenium and Vitamin E Cancer Prevention Trial (SELECT)) have produced disappointing findings.1 Multivitamin supplements, however, may yield greater benefit and less risk, since the nutrient profile more closely approximates a healthy, balanced diet. A randomised controlled trial (RCT) of multivitamin supplements is significant since over one-third of US adults regularly take these preparations.2


Gaziano and colleagues recently reported …

View Full Text


  • Competing interests None.