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Vitamin E is ineffective in preventing stroke
  1. Francesco Brigo1,2,
  2. Monica Storti3,
  3. Frediano Tezzon2,
  4. Raffaele Nardone2,4
  1. 1Department of Movement Sciences, Section of Clinical Neurology, University of Verona, Verona, Italy
  2. 2Division of Neurology, Franz Tappeiner Hospital, Merano, Italy
  3. 3Division of Internal Medicine, Franz Tappeiner Hospital, Merano, Italy
  4. 4Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria
  1. Correspondence to Dr Francesco Brigo
    Department of Movement Sciences, Section of Clinical Neurology, University of Verona, Piazzale LA Scuro, Verona10 - 37134, Italy; dr.francescobrigo{at}

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Stroke is a leading cause of death and long-term disability worldwide. Vitamin E (tocopherol) is an antioxidant which may protect against atherogenesis by acting as a scavenger of free radicals with subsequent reduced oxidation of low-density lipoprotein cholesterol and several other favourable effects on plaque stability, platelet aggregation and tendency to thrombosis.

However, a recent meta-analysis of 13 randomised controlled trials (166 282 participants) showed that, compared with placebo, vitamin E supplementation does not significantly prevent stroke of any type (RR 1.01; 95% CI 0.96 to 1.07).1 The statistical question addressed by this meta-analysis was whether or not vitamin E …

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  • Contributors FB and MS conceived the idea. FB performed analysis. RN and FT revised the manuscript for important intellectual content. All the authors approved the final version of the manuscript.

  • Competing interests None.

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