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Randomised controlled trial
A Mediterranean diet supplemented with olive oil or nuts reduces the incidence of major cardiovascular events in high-risk patients
  1. Demosthenes Panagiotakos
  1. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
  1. Correspondence to : Professor Demosthenes Panagiotakos, Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou, Athens 17671, Greece; dbpanag{at}

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Commentary on: OpenUrlCrossRefPubMedWeb of Science


The Mediterranean diet has long been associated with lower risk for cardiovascular disease (CVD) events, which is mainly based on results from observational studies.


The PREDIMED study was a well-designed, large-scale randomised trial of 7447 middle-aged participants from Spain with high cardiovascular risk but no CVD. The participants were allocated to three groups: a Mediterranean diet supplemented with extravirgin olive oil (group 1), a Mediterranean diet supplemented with nuts (group 2) and a control group that followed a healthy diet with strong advice to reduce dietary fat (group 3). The primary endpoint of the …

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  • Competing interests None.