Article Text

Download PDFPDF
Systematic review and meta-analysis
Central venous catheters coated or impregnated with antimicrobial agents effectively prevent microbial colonisation and catheter-related bloodstream infections
  1. Mark E Rupp
  1. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
  1. Correspondence to : Dr Mark E Rupp, Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA; merupp{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlPubMed


A total of 78 000 catheter-related bloodstream infections (CRBSI) occur in US hospitals and dialysis units annually, resulting in a mortality rate of 12.3% and an excess cost of US$7288–US$29 156/case. A commonly used and guideline-supported strategy to prevent CRBSI is to use a central venous catheter (CVC) that has been impregnated with antimicrobial agents.


Lai and colleagues performed a systematic review of randomised controlled trials (RCTs) that studied any type of coated CVC compared with either a non-coated CVC or CVC with another coating. The major outcomes of interest were clinically diagnosed sepsis, CRBSI and mortality. A comprehensive search strategy was used. The Cochrane data extraction method was utilised with two reviewers independently evaluating study relevance and risk of bias. …

View Full Text


  • Competing interests MER reports grants and personal fees from 3M, grants and personal fees from Molnlycke and personal fees from Baxter outside the submitted work.