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Systematic review and meta-analysis
Cardiovascular benefits of HRT may differ by patient age
  1. Giuseppe Rosano,
  2. Cristiana Vitale
  1. Department of Medical Sciences, IRCCS San Raffaele, Rome, Italy
  1. Correspondence to : Professor Giuseppe Rosano, Department of Medical Sciences, IRCCS San Raffaele, Via della Pisana 235, Rome 00163, Italy; giuseppe.rosano{at}

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In early postmenopausal women oestrogen and/or hormone replacement therapy (ERT/HRT) are used to alleviate symptoms and reduce the probability of diseases related to ovarian hormones deprivation. However, in late postmenopausal women the initiation of HRT has a negative risk/benefit balance mainly because of the increased risk of cardiovascular diseases (CVD).


Main et al performed a meta-analysis of randomised controlled trials (RCTs) comparing oral ERT/HRT with either a placebo or a no-treatment control for 6 months or longer. Included in the analysis were those women with the evidence of being menopausal either with or without evidence of existing CVD.

Two authors assessed study quality and extracted data from those references …

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  • Competing interests None.