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Randomised controlled trial
Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes
  1. Nichola J Davis,
  2. Gayotri Goswami
  1. Department of Medicine, North Central Bronx Hospital, Bronx, New York, USA
  1. Correspondence to : Dr Nichola J Davis, Department of Medicine, North Central Bronx Hospital, 3424 Kossuth Avenue, Bronx, NY 10461, USA; nichola.davis{at}

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Commentary on: OpenUrlCrossRefPubMedWeb of Science


Diet, physical activity and weight loss are recommended in the management of type 2 diabetes. This recommendation is largely based on short-term intervention studies which show improvements in cardiovascular risk factors including glycaemic control, lipids, blood pressure and inflammation. The Look AHEAD (Action for Health in Diabetes) randomised controlled trial (RCT) studied the impact of long-term weight loss through an intensive lifestyle intervention on cardiovascular morbidity and mortality in type 2 diabetes.


Look AHEAD is a multicentre, RCT. A total of 5145 adults aged 45–75 years with type 2 diabetes were randomised to receive either an intensive lifestyle intervention (n=2570) or control (n=2575). The intervention …

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  • Competing interests None.