Article Text

Download PDFPDF
Systematic review
Individual clinical symptoms have limited utility in the diagnosis of obstructive sleep apnoea
  1. Reena Mehra
  1. Sleep Disorders Research, Neurologic Institute, Cleveland Clinic, Cleveland, Ohio, USA
  1. Correspondence to: Dr Reena Mehra, Sleep Disorders Research, Neurologic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; reena.mehra{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlCrossRefPubMedWeb of Science


The accurate clinical diagnosis of obstructive sleep apnoea (OSA) has been elusive, leading to reliance on objective testing via polysomnography. However, various clinical prediction algorithms and questionnaires have been developed to estimate the pretest probability of OSA which have proven clinically useful and have served to effectively inform decisions over whether or not to proceed with objective sleep testing. These include the Berlin Questionnaire, Sleep Apnoea Clinical Score and the STOP-Bang questionnaires.1–3


The authors performed a systematic review of the literature from 1966 to 2013 to examine the …

View Full Text


  • Competing interests RM reports grants from NIH, personal fees from Care Core Medical Advisory Board, personal fees from American Academy of Sleep Medicine. Case Western Reserve University has received positive airway pressure machines and associated supplies from Philips Respironics for NIH-funded research, for which RM serves as the Principal Investigator.